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Case study: Pediatrics, Management

Using FeNO to Improve Adherence and Control Life-Threatening Asthma

An adolescent girl with severe, life-threatening asthma was referred for biologic treatment after repeated episodes of poor control. FeNO testing helped educate the family on the importance of medication adherence, dramatically improving her condition.

Last updated: September 2026

Patient profile

Gender/Age: Adolescent female
History: Lived with grandparents, both of whom had asthma and COPD

Symptoms

  • Severe asthma with life-threatening attacks

Management Approach:

The patient was started on high-dose steroids and biologics. Initially, she took her medication, but she began losing weight, which was concerning given her steroid use. Screening for other conditions like diabetes came back normal.

The patient’s grandmother was asked to supervise her medication intake to ensure all prescriptions were collected and administered properly.

FeNO Test:255 ppb, a high level indicating severe eosinophilic inflammation and uncontrolled asthma. This result was an eye-opener for both the patient and her family, highlighting the life-threatening risk of not adhering to her asthma medication.

Treatment Plan:

Education and Supervision The FeNO results helped the family understand the importance of consistent medication use. With this knowledge, the patient’s grandmother ensured proper supervision of her treatment.
Monthly Follow-up: The patient was monitored closely, with monthly follow-ups to track her progress and adjust treatment as needed.

Outcome:

  • Over time, the patient’s FeNO levels decreased, her lung function improved, and she was able to reduce her treatment to minimal levels.
  • Four years later, she remains stable with normal lung function and controlled asthma on minimal medication.

Clinical Takeaway:

FeNO testing was a turning point in this patient’s care, providing clear evidence of the severe airway inflammation. The test played a keyrole in educating the family about the impacts of poor adherence, leading to better asthma control and significantly improved outcomes.

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