Important Safety Information | NIOX VERO® User Manual (PDF)

For US Healthcare Professionals Only

For questions about coronavirus/COVID-19 and using NIOX VERO®, please visit the NIOX VERO Coronavirus/COVID-19 FAQ.


Accurately measure airway inflammation with NIOX VERO®

NIOX VERO® is one of the most used FeNO testing devices in the world.1

NIOX VERO® - FeNO Testing Device
Paitent Exhaling into NIOX VERO® - FeNO Testing Device

Designed to help diagnose and manage asthma

Asthma’s complexity and heterogeneity means that it’s not always easy to feel confident in diagnosis and management.2 Poorly controlled asthma can have long term consequences for patients.3,4,5


Patient outcomes with FeNO

FeNO testing is now recommended for asthma care in guidelines across the globe.6,7 An accurate FeNO testing device can assist in diagnosing and managing asthma, and can help to optimize your treatment decision. The current ATS FeNO thresholds were derived from trials where NIOX technology was the most widely used device.7,8 Studies show that results from other FeNO testing devices are not interchangeable with NIOX.9,10,11,12,13


Designed to give an accurate reading in only one measurement.14

NIOX VERO accurately measures airway inflammation

Reassuring reproducibility enables an accurate result to be delivered in a single test.

Removal of Ambient Nitric Oxide

Removal of enviromental NO

Environmental NO levels can vary significantly and have the potential to impact the accuracy of FeNO testing.15 The NIOX NO scrubber eliminates the impact of ambient NO, helping to ensure accuracy and reproducibility irrespective of the surroundings and environment.

Test completed in approximately 1 min - NIOX VERO

Result in ~1 minute

Once the test have been completed, it takes approximately 1 minute to produce the accurate FeNO result for your patient.

Number 1

From Circassia

Circassia, the first to develop a point-of-care FeNO device over 20 years ago.



NIOX VERO® automatically performs self-checks when the device is switched on. All sensors are individually calibrated during manufacturing to ensure accuracy through their stated lifetime without any need to re-calibrate.


Devices are not interchangeable

Due to variations in sensor technology, other FeNO devices are not directly interchangeable with NIOX.9,10,11,12,13

NIOX VERO® Animations

Excellent user experience

NIOX VERO is easy to use for healthcare professionals and patients alike. A choice of three engaging animations along with the optional inclusion of NIOX Apps (NIOX Panel and NIOX Patient) provide the flexibility to tailor the experience as needed. The NIOX VERO device is lightweight and portable allowing easy movement within the clinical setting.

NIOX VERO® Animations

NIOX VERO can make a difference in the management of asthma.

In one study, after FeNO measurement, clinicians modified their treatment plan in 31% of cases of which 90% involved changes to ICS medications.2 Studies have also shown up to a 50% reduction in exacerbations where NIOX has been used to regularly test asthma patients in a clinical setting.16,17

Book a Demo of NIOX VERO® in your practice.

Want to see how NIOX VERO® could help you accurately diagnose and manage asthma? Fill in the form below.

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References: 1. Data on file. Circassia Ltd. May 2020. C-NIOX-0006. 2. Hanania NA et al. Measurement of fractional exhaled nitric oxide in real-world clinical practice alters asthma treatment decisions. Ann Allergy Asthma Immunol. 2018 120(4):414-418. 3. Sears MR. Lung function decline in asthma. Eur Respir J. 2007 30(3):411-3. 4. Bai TR et al. Severe exacerbations predict excess lung function decline in asthma. Eur Respir J. 2007 30(3):452-6. 5. O’Byrne PM et al. Severe exacerbations and decline in lung function in asthma. Am J Respir Crit Care Med. 2009 179(1):19-24. 6. National Institute for Health and Clinical Excellence (NICE). Asthma: diagnosis, monitoring and chronic asthma management. NICE guideline [NG80]. 2017. 7. Dweik RA, Boggs PB, Erzurum SC, et al; on behalf of the American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FeNO) for Clinical Applications. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FeNO) for clinical applications. Am J Respir Crit Care Med. 2011;184:602-615.  8. Data on file. Circassia Ltd. October 2019 C-NIOX-0001. 9. Huang T et al. Fractional exhaled nitric oxide measurement: Comparison between the Sunvou-CA2122 analyzer and the NIOX VERO analyzer. J Asthma. 2019 12:1-8. 10. Molino A et al. Comparison of three different exhaled nitric oxide analyzers in chronic respiratory disorders. J Breath Res. 2019 13(2):021002. 11. Saito et al. Comparison of fractional exhaled nitric oxide levels measured by different analyzers produced by different manufacturers. J Asthma. 2019 22:1-11. 12. Kapande KM et al. Comparative repeatability of two handheld fractional exhaled nitric oxide monitors. Pediatr Pulmonol. 2012 47(6):546-50. 13. Tsuburai T et al. Differences in fraction of exhaled nitric oxide values measured by two hand-helded analysers. Arerugi. 2017 66(3):204-208. 14. Alving K et al. Validation of a New Portable Exhaled Nitric Oxide Analyzer, NIOX VERO®: Randomized Studies in Asthma. Pulm Ther. 2017 3(1):207-218. 15. Clapp LJ, Jenkin ME. Analysis of the relationship between ambient levels of O3, NO2 and NO as a function of NOx in the UK. Atmos Env. 2001;35:6391-6405. 16. Syk J et al. Anti-inflammatory treatment of atopic asthma guided by exhaled nitric oxide: a randomized, controlled trial. J Allergy Clin Immunol Pract. 2013 1(6):639-48. 17. Petsky H. Exhaled nitric oxide in children with asthma. Respiratory care nurse’s perspective. Indian Pediatr. 2014;51(2):102-103.