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Case study: Diagnosis

Using FeNO to Uncover Eosinophilic Inflammation

A man in his 60s presented with persistent breathlessness after being discharged from the respiratory team, where no cause for his symptoms was identified. He was awaiting further cardiology investigations but sought help for ongoing respiratory issues.

Last updated: September 2026

Patient profile

Gender/Age: Male in his 60s
History: Recently discharged from secondary care respiratory team without a clear diagnosis; referred to cardiology for further investigations

Symptoms

  • Daily persistent breathlessness despite previous treatments

Challenges and Diagnostic Approach:

Despite multiple evaluations by the respiratory team, the underlying cause of his breathlessness was not identified. The patient had not received a FeNO test during his secondary care assessment.

FeNO Test: Significantly elevated, indicating eosinophilic airway inflammationhma

Treatment Plan:

Inhaled Corticosteroid (ICS): Based on the high FeNO results, treatment with an inhaled corticosteroid was initiated.

Outcome:

  • The patient experienced a dramatic improvement in his respiratory symptoms following the ICS treatment. The cardiology referral was canceled as the cause of his breathlessness was effectively treated.

Clinical Takeaway:

FeNO testing revealed the presence of eosinophilic inflammation that had been missed in previous assessments. This insight allowed for tailored treatment, avoiding unnecessary cardiology investigations and dramatically improving the patient’s condition.

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