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38-Year-Old Female With Chronic Cough*

Role of FeNO

Role of FeNO

FeNO testing helped guide an appropriate workup and diagnosis of this patient and helped avoid an expensive immunodeficiency workup that would not have been useful.

Patient Background

Patient Background

  • Referred for possible immunodeficiency
  • Patient presented with a worsening shortness of breath, chest tightness, and coughing, especially in the previous 2 weeks
  • Described itchy, watery eyes, congestion, and drainage when around cats and also in the spring, summer, and fall
  • Frequent bronchitis, sinusitis, and strep throat over the previous 6 months
  • Previous pulmonary function tests were reportedly normal
  • No previous known history of allergy or asthma
  • No past or current medications for her condition
NIOX-Guided Assessment

NIOX-Guided Assessment

  • Her fractional exhaled nitric oxide (FeNO) measurement was 52 ppb suggesting significant airway inflammation
  • Pulmonary function tests and chest x-ray were both normal
  • Allergy test results were positive for cats, dogs, trees, grasses, and weeds


  • Treated for asthma aggressively with oral steroids for 5 days
  • Started a combination inhaled corticosteroid and long-acting beta agonist

Continuously improving, the patient had a resolution of asthma symptoms and has been well controlled since starting appropriate treatment.

Posttreatment FeNO was 16 ppb

*The case study presented is for educational purposes only and does not represent a real patient case. Similar results cannot be guaranteed and should not be considered typical.