Product References


1. Hemmingsson T, Linnarsson D, Gambert R. Novel Hand-held device for exhaled nitric oxide analysis in research and clinical applications. J Clin Moni Comput 2004;18:379-87.


2. Alving K, Jansson C, Nordvall L. Performance of a new hand-held device for exhaled nitric oxide measurement in adults and children. Respir Res 2006;7:67.

3. Gill M, Graff GR, Adler AJ, Dweik RA. Validation study of fractional exhaled nitric oxide measurements using a handheld monitoring device. J Asthma. 2006;43(10):731-4.

4. McGill C, Malik G, Turner S. Validation of a hand-held exhaled nitric oxide analyzer for use in children. Pediatr Pulmonol. 2006 Nov;41(11):1053-7.

5. Pijnenburg MW, Floor SE, Hop WC, De Jongste JC. Daily ambulatory exhaled nitric oxide measurements in asthma. Pediatr Allergy Immunol.2006;17(3):189-93.

6. Vahlkvist, S, Sinding M, Skamstrup K, Bisgaard H, Daily home measurements of exhaled nitric oxide in asthmatic children during natural birch pollen exposure. J Allergy Clin Immunol, 2006;117(6):1272-6.
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7. Bodini A, Peroni D, Loiacono A, Costella S, Pigozzi R, Baraldi E, Boner AL, Piacentini GL, Exhaled nitric oxide daily evaluation is effective in monitoring exposure to relevant allergens in asthmatic children. Chest, 2007;132(5):1520-5.
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8. Chen W, Purohit A, Barnig C, Casset A, de Blay F. Niox and Niox Mino: comparison of exhaled NO in grass pollen allergic adult volunteers. Allergy. 2007;62(5):571-2.
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9. Fortuna AM, Feixas T, Casan P, Measurement of fraction of exhaled nitric oxide with the portable NIOX-MINO monitor in healthy adults. Arch Bronconeumol, 2007;43(3):176-9.
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10. Khalili B, Boggs PB, Bahna SL. Reliability of a new hand-held device for the measurement of exhaled nitric oxide. Allergy 2007;62:1171-1174.
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11. Menzies D, Nair A, Lipworth BJ. Portable exhaled nitric oxide measurement: Comparison with the "gold standard" technique. Chest 2007;131(2):410-4. 
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12. Sardón Prado O, Aldasoro Ruiz A, Korta Murua J, Mintegui Aramburu J, Emparanza Knorr JI, Pérez-Yarza EG. Agreement between two devices for measuring exhaled nitric oxide. An Pediatr (Barc). 2007;67(6):572-7.
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13. Berg J, Lindgren P. Economic evaluation of FE(NO) measurement in diagnosis and 1-year management of asthma in Germany. Respir Med. 2008;102(2):219-31.

14. Boot JD., de Ridder L, de Kam ML, Calderon C, Mascelli MA, Diamant Z, Comparison of exhaled nitric oxide measurements between NIOX MINO ® electrochemical and Ecomedics chemiluminescence analyzer. Respir Med, 2008;102(11):1667-71.

15. Chladkova J, Havlinova Z, Chyba T, Krcmova I, Chladek J, Analysis of single-breath profiles of exhaled nitric oxide in children with allergy and asthma: guideline-derived plateau concentrations compared to results of automatic evaluation by two analyzers. J Asthma, 2008;45(9):820-6.

16. Kostikas K, Papaioannou AI, Tanou K, Koutsokera A, Papala M, Gourgoulianis KI. Portable exhaled nitric oxide as a screening tool for asthma in young adults during pollen season. Chest. 2008 Apr;133(4):906-13. 
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 de Laurentiis, G, Maniscalco M, Cianciulli F, Stanziola A, Marsico S, Lundberg JO, Weitzberg E, Sofia M, Exhaled nitric oxide monitoring in COPD using a portable analyzer. Pulm Pharmacol Ther, 2008;21(4):689-93.

 Hewitt RS, Modrich CM, Medlicott T, Cowan JO, Taylor DR, Supporting the diagnosis of non-specific respiratory symptoms in primary care: the role of exhaled nitric oxide measurement and spirometry. Prim Care Respir J. 2008;17(2):97-103.
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19. Maniscalco M, de Laurentiis G, Weitzberg E, Lundberg JO, Sofia M, Validation study of nasal nitric oxide measurements using a hand-held electrochemical analyser. Eur J Clin Invest, 2008;38(3):197-200.

20. Pizzimenti S, Bugiani M, Piccioni P, Heffler E, Carosso A, Guida G, Rolla G, Exhaled nitric oxide measurements: correction equation to compare hand-held device to stationary analyzer. Respir Med, 2008;102(9):1272-5.

21. Sardón Prado O, Pérez-Yarza EG, Aldasoro Ruiz A, Korta Murua J, Mintegui Aranburu J, Emparanza Knörr JI. Fractional exhaled nitric oxide: Validation of a 6 second exhalation time with two different analysers. An Pediatr (Barc). 2008;69(3):221-6.
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22. Takalo R, Piirilä P. Sovijärvi AR. Repeatability of successive measurements with a portable nitric oxide analyser in patients with suggested or diagnosed asthma. Scand J Clin Lab Invest. 2008;68(8):830-2. 

23. Torre O, Olivieri D, Barnes PJ, Kharitonov SA. Feasibility and interpretation of FE(NO) measurements in asthma patients in general practice. Respir Med. 2008;102(10):1417-24.

24. Weschta M, Deutschle T, Riechelmann H, Nasal fractional exhaled nitric oxide analysis with a novel hand-held device. Rhinology, 2008;46(1):23-7.


25. Diaz Vazquez C, Carvajal Uruena I, Cano Garcinuno A, Mora Gandarillas I, Mola Caballero de Rodas P, Garcia Merino A, Dominguez Aurrecoechea B, Feasibility of FeNO measurement in asthmatic children in the primary care setting. CANON Study. An Pediatr (Barc), 2009;71(3):209-14.
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26. de Jongste JC, Carraro S, Hop WC; CHARISM Study Group, Baraldi E. Daily telemonitoring of exhaled nitric oxide and symptoms in the treatment of childhood asthma. Am J Respir Crit Care Med. 2009 Jan 15;179(2):93-7.
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 Dinakar C, Exhaled nitric oxide in pediatric asthma. Curr Allergy Asthma Rep. 2009;9(1):30-7.

 Price D, Berg J, Lindgren P. An economic evaluation of NIOX MINO ® airway inflammation monitor in the United Kingdom. Allergy. 2009 Mar;64(3):431-8.
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 Hemmingsson T, Horn A, Linnarsson D. Measuring exhaled nitric oxide at high altitude. Respir Physiol Neurobiol. 2009 Jul 31;167(3):292-8. Epub 2009 Jun 11.

 Schiller B, Hammer J, Barben J, Trachsel D, Comparability of a hand-held nitric oxide analyser with online and offline chemiluminescence-based nitric oxide measurement. Pediatr Allergy Immunol, 2009;20(7)679-85.

 Schneider A, Tilemann L, Schermer T, Gindner L, Laux G, Szecsenyi J, Meyer FJ. Diagnosing asthma in general practice with portable exhaled nitric oxide measurement--results of a prospective diagnostic study. Respir Res. 2009;10:15. Erratum in: Respir Res. 2009;10: 64
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 Tamasi L, Bohacs A, Bikov A, Andorka C, Rigo Jr J, Losonczy G, Horvath I, Exhaled nitric oxide in pregnant healthy and asthmatic women. J Asthma, 2009;46(8):786-91.

Thomas M, Stonham C. How can I measure airways inflammation in asthma? The British Primary Care Nursing 2009;3(2):23-6. [Free full text article]


34. Ito Y, Adachi Y, Itazawa T, Okabe Y, Adachi YS, Katsumuma T, Miyawaki T, Comparison of exhalation time methods (6 sec vs. 10 sec) of a hand-held exhaled nitric oxide analyzer. Pediatr Pulmonol. 2010 Oct;45(10):1005-8.

 Maniscalco M, Lundberg JO, Handheld nitric oxide sensor NIOX MINO ® for the monitoring of respiratory disorders. Expert Rev Respir Med. 2010 Dec;4(6):715-21.

Matsunaga K, Hirano T, Kawayama T, Tsuburai T, Nagase H, Aizawa H, Akiyama K, Ohta K, Ichinose M. Reference Ranges for Exhaled Nitric Oxide Fraction in Healthy Japanese Adult Population. Allergol Int. 2010 Dec;59(4):363-7.
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 Pérez-de-Llano LA, Carballada F, Castro Añón O, Pizarro M, Golpe R, Baloira A, Vázquez Caruncho M, Boquete M. Exhaled nitric oxide predicts control in patients with difficult-to-treat asthma. Eur Respir J. 2010;35(6):1221-7.

Prieto L, Palacios R, Aldana D, Ferrer A, Perez-Frances C, Lopez V, Rojas R.Effect of allergen-specific immunotherapy with purified Alt a1 on AMP responsiveness, exhaled nitric oxide and exhaled breath condensate pH: a randomized double blind study. Allergy Asthma Clin Immunol. 2010; 6(1): 27. 
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 Saito J, Fukuhara A, Sato Y, Sato S, Saito K, Nakagawa N, Inokoshi Y, Ishii T, Tanino Y, Ishida T, Munakata M, Differences of fractional exhaled nitric oxide (FeNO) levels performed using two different analyzers. Nihon Kokyuki Gakkai Zasshi, 2010;48(1):17-22.

 Selby A, Clayton B, Grundy J, Pike K, Drew K, Raza A, Kurukulaaratchy R, Arshad SH, Roberts G, Are exhaled nitric oxide measurements using the portable NIOX MINO ® repeatable? Respir Res, 2010;11:43.
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41. Baumann LM, Robinson CL, Combe JM, Gomez A, Romero K, Gilman RH, Cabrera L, Hansel NN, Wise RA, Breysse PN, Barnes K, Hernandez JE, Checkley W. Effects of distance from a heavily transited avenue on asthma and atopy in a periurban shantytown in Lima, Peru. J Allergy Clin Immunol, 2011. 127(4): p. 875-82.
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42. Bloemen K, Van Den Heuvel R, Govarts E, Hooyberghs J, Nelen V, Witters E, Desager K, Schoeters G. A new approach to study exhaled proteins as potential biomarkers for asthma. Clin Exp Allergy, 2011. 41(3): p. 346-56.

 Bozek A, Krajewska J, Jarzab J. Nasal nitric oxide and other diagnostic procedures in seasonal allergic rhinitis: elderly vs juvenile patients. Am J Otolaryngol, 2011. 32(2): p. 105-8.

Carlstedt F, Lazowska D, Bornehag CG, Olin AC, Hasselgren M. Exhaled nitric oxide and urinary EPX levels in infants: a pilot study. Clin Mol Allergy, 2011. 9(1): p. 8. (Download free full text article) 

45. Clearie KL, Jackson CM, Fardon TC, Williamson PA, Vaidyanathan S, Burns P, Lipworth BJ. Supervised step-down of inhaled corticosteroids in the community--an observational study. Respir Med, 2011. 105(4): p. 558-65.

Corren J, Lemanske RF, Hanania NA, Korenblat PE, Parsey MV, Arron JR, Harris JM, Scheerens H, Wu LC, Su Z, Mosesova S, Eisner MD, Bohen SP, Matthews JG, Lebrikizumab Treatment in Adults with Asthma. N Engl J Med, 2011.
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 Czecior E, Grzanka A, Kasperski J, Misiolek M, Kasperska-Zajac A. Exhaled nitric oxide in patients with early glottic cancer. Eur J Cancer Prev. 2011 May 26. [Epub ahead of print]

Donnelly J, Cowan DC, Yeoman DJ, Lucas SJ, Herbison GP, Thomas KN, Ainslie PN, Taylor DR. Exhaled nitric oxide and pulmonary artery pressures during graded ascent to high altitude. Respir Physiol Neurobiol, 2011. 177(3): p. 213-7.

 Ekstrand Y, Ternesten-Hasseus E, Arvidsson M, Lofdahl K, Palmqvist M, Millqvist E. Sensitivity to Environmental Irritants and Capsaicin Cough Reaction in Patients with a Positive Methacholine Provocation Test before and after Treatment with Inhaled Corticosteroids. J Asthma, 2011. 48(5): p. 482-9.

 Fell AK, Noto H, Skogstad M, Nordby KC, Eduard W, Svendsen MV, Ovstebo R, Troseid AM, Kongerud J. A cross-shift study of lung function, exhaled nitric oxide and inflammatory markers in blood in Norwegian cement production workers. Occup Environ Med, 2011. 68(11): p. 799-805.
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 Hakim F, Hellou E, Goldbart A, Katz R, Bentur Y, Bentur L. The acute effects of water-pipe smoking on the cardiorespiratory system. Chest, 2011. 139(4): p. 775-81.

 Halterman JS, Riekert K, Bayer A, Fagnano M, Tremblay P, Blaakman S, Borrelli B. A Pilot Study to Enhance Preventive Asthma Care among Urban Adolescents with Asthma. J Asthma, 2011. 48(5): p. 523-30.

 Hashimoto S, Brinke AT, Roldaan AC, van Veen IH, Möller GM, Sont JK, Weersink EJ, van der Zee JS, Braunstahl GJ, Zwinderman AH, Sterk PJ, Bel EH. Internet-based tapering of oral corticosteroids in severe asthma: a pragmatic randomised controlled trial. Thorax. 2011 Jun;66(6):514-20. Epub 2011 Apr 7.

Hillas G, Kostikas K, Mantzouranis K, Bessa V, Kontogianni K, Papadaki G, Papiris S, Alchanatis M, Loukides S, Bakakos P. Exhaled nitric oxide and exhaled breath condensate pH as predictors of sputum cell counts in optimally treated asthmatic smokers. Respirology, 2011. 16(5): p. 811-8.

Ito Y, Adachi Y, Itazawa T, Okabe Y, Adachi YS, Higuchi O, Katsunuma T, Miyawaki T: Association between the Results of the Childhood Asthma Control Test and Objective Parameters in Asthmatic Children. J Asthma, 2011. 48(10): p. 1076-80.

 Kalliola S, Malmberg P, Rito T, Pelkonen AS, Mäkelä MJ. Can we use portable nitric oxide analyzer in young children? Pediatr Pulmonol. 2011 Jul;46(7):627-31. doi: 10.1002/ppul.21390. Epub 2011 Jun 1.

 Kilic H, Oguzulgen IK, Bakir F, Turktas H. Asthma in obese women: outcomes and factors involved. J Investig Allergol Clin Immunol, 2011. 21(4): p. 290-6.
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 Koster ES, Raaijmakers JA, Vijverberg SJ, Maitland-van der Zee AH. Inhaled corticosteroid adherence in paediatric patients: the PACMAN cohort study. Pharmacoepidemiol Drug Saf, 2011. 20(10): p. 1064-72.

 Matsunaga K, Hirano T, Akamatsu K, Koarai A, Sugiura H, Minakata Y, Ichinose M. Exhaled Nitric Oxide Cutoff Values for Asthma Diagnosis According to Rhinitis and Smoking Status in Japanese Subjects. Allergol Int, 2011. 60(3): p. 331-7. 

60. McCurdy MR, Wazni MW, Martinez J, McAleer MF, Guerrero T. Exhaled nitric oxide predicts radiation pneumonitis in esophageal and lung cancer patients receiving thoracic radiation. Radiother Oncol, 2011. 101(3): p. 443-8.

 Montella S, Alving K, Maniscalco M, Sofia M, De Stefano S, Raia V, Santamaria F. Measurement of nasal nitric oxide by hand-held and stationary devices. Eur J Clin Invest, 2011.

 Neurohr C, Huppmann P, Leuschner S, von Wulffen W, Meis T, Leuchte H, Ihle F, Zimmermann G, Baezner C, Hatz R, Winter H, Frey L, Ueberfuhr P, Bittmann I, Behr J. Usefulness of exhaled nitric oxide to guide risk stratification for bronchiolitis obliterans syndrome after lung transplantation.Am J Transplant, 2011. 11(1): p. 129-37.

 Ozier A, Girodet PO, Bara I, Tunon de Lara JM, Marthan R, Berger P. Control maintenance can be predicted by exhaled NO monitoring in asthmatic patients. Respir Med. 2011 Jul;105(7):989-96.  

Pacheco A, Faro V, Cobeta I, Royuela A, Molyneux I, Morice AH. Gastro-oesophageal reflux, eosinophilic airway inflammation and chronic cough.Respirology, 2011. 16(6): p. 994-9.

 Pala G, Pignatti P, Moscato G. The use of fractional exhaled nitric oxide in investigation of work-related cough in a hairdresser. Am J Ind Med. 2011 Jul;54(7):565-8. doi: 10.1002/ajim.20948. Epub 2011 Mar 10.

 Pérez Tarazona S, Martínez Camacho RM, Alfonso Diego J, Escolano Serrano S, Talens Gandía J. Diagnostic value of exhaled nitric oxide measurement in mild asthma. An Pediatr (Barc). 2011 Jun 22. [Epub ahead of print] Spanish.
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 Ritz T, Ayala ES, Trueba AF, Vance CD, Auchus RJ. Acute Stress-induced Increases in Exhaled Nitric Oxide in Asthma and Their Association with Endogenous Cortisol. Am J Respir Crit Care Med, 2011. 183(1): p. 26-30.

Robinson CL, Baumann LM, Romero K, Combe JM, Gomez A, RH Gilman, Cabrera L, Gonzalvez G, Hansel NN, Wise RA, Barnes KC, Breysse PN, Checkley W. Effect of urbanisation on asthma, allergy and airways inflammation in a developing country setting. Thorax, 2011. 66(12): p. 1051-7.

 Sastre J, Madero MF, Fernandez-Nieto M, Sastre B, Del Pozo V, Potro MG, Quirce S. Airway response to chlorine inhalation (bleach) among cleaning workers with and without bronchial hyperresponsiveness. Am J Ind Med, 2011. 54(4): p. 293-9. 

70. Sordillo JE, Webb T, Kwan D, Kamel J, Hoffman E, Milton DK, Gold DR. Allergen exposure modifies the relation of sensitization to fraction of exhaled nitric oxide levels in children at risk for allergy and asthma. J Allergy Clin Immunol, 2011. 127(5): p. 1165-1172 e5.

Taylor DR, Palmay R, Cowan JO, Herbison GP. Long term performance characteristics of an electrochemical nitric oxide analyser. Respir Med, 2011. 105(2): p. 211-7.

Tilemann L, Gindner L, Meyer F, Szecsenyi J, Schneider A. Differences in local and systemic inflammatory markers in patients with obstructive airways disease. Prim Care Respir J, 2011. 20(4):407-14.
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 Weichenthal S, Kulka R, Dubeau A, Martin C, Wang D, Dales R. Traffic-related air pollution and acute changes in heart rate variability and respiratory function in urban cyclists. Environ Health Perspect, 2011. 119(10): p. 1373-8.

 Zeiger RS, Schatz M, Zhang F, Crawford WW, Kaplan MS, Roth RM, Chen W. Association of exhaled nitric oxide to asthma burden in asthmatics on inhaled corticosteroids. J Asthma. 2011 Feb;48(1):8-17. Epub 2010 Dec 15.

Xu F, Zou Z, Yan S, Li F, Kan H, Norback D, Wieslander G, Xu J, Zhao Z. Fractional exhaled nitric oxide in relation to asthma, allergic rhinitis, and atopic dermatitis in chinese children. J Asthma, 2011. 48(10): p. 1001-6. 


76. Castano R, Miedinger D, Ghezzo H, Vandenplas O, Malo JL. Feasibility of monitoring nasal and exhaled nitric oxide with a handheld analyzer during specific inhalation challenge. Ann Allergy Asthma Immunol, 2012. 108(1): p. 65-6. (Letter)

77. Kersten ET, van Leeuwen JC, Brand PL, Duiverman EJ, de Jongh FH, Thio BJ, Driessen JM. Effect of an intranasal corticosteroid on exercise induced bronchoconstriction in asthmatic children. Pediatr Pulmonol, 2012. 47(1): p. 27-35.
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78. Lombardi C, Passalacqua G, Canonica GW. The functional connection between oral allergy syndrome and united airways disease assessed by oral challenge. Ann Allergy Asthma Immunol, 2012. 108(1): p. 30-3.

Additional References

A. Medical Design Excellence Award 2005

B. Industrial Excellence Awards 2005

C.  ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide, 2005. Am J Respir Crit Care 2005;171:912-30.  
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D. Dweik RA., Boggs PB, Erzurum SC, Irvin CG, Leigh MW, Lundberg JO, Olin AC, Plummer AL, Taylor DR. An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications.Am J Respir Crit Care Med, 2011. 184(5): p. 602-615.
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More than 1500 publications in peer-review medical journals confirms the clinical value of exhaled NO measurements. Access the abstracts of these articles from the Aerocrine website.