What is FeNO?
FeNO is an Objective Biomarker of Airway Inflammation1,2
Fractional Exhaled nitric oxide (FeNO) is a quantitative, noninvasive, simple, and safe method of measuring airway inflammation that provides a complementary tool to other ways of assessing airways disease in asthma patients.
Specifically, FeNO is an objective measurement of allergic/eosinophilic inflammation. Airway inflammation results from the activation of mast cells and antigen-specific T-helper cells type 2 (Th2) resulting in the production of cytokines including interleukin (IL)-4, IL-5, and IL-13.3 This is an important distinction as Th2 allergic inflammation and eosinophilic inflammation are not one in the same. However, they are very closely associated with similar molecular pathways and crossover.
- In Diagnosis of Asthma and Identifies Patients with Th2/Type 2 Allergic/Eosinophilic Inflammation
- Determine Steroid Responsiveness and Optimize the Dose of Inhaled Steroids
- Uncover Non-Adherence to Inhaled Corticosteroids
- Reduce the Likelihood of Exacerbations in Patients at Risk for Future Events
- Identify Asthmatics Who Are Possible Candidates for Treatment with a Biologic